- Zaftig: (of a person, especially a woman) having a full, rounded figure; plump.
- Zany: Amusingly unconventional and idiosyncratic.
- Zarzuela: A Spanish traditional form of musical theatre that alternates between spoken and sung scenes.
- Zealot: A person who is fanatical and uncompromising in pursuit of their religious, political, or other ideals.
- Zephyr: A soft gentle breeze.
- Zeugma: A figure of speech in which a word applies to multiple parts of the sentence.
- Ziggurat: A rectangular stepped tower, sometimes surmounted by a temple. Ziggurats are first attested in the late 3rd millennium BC and probably inspired the biblical story of the Tower of Babel.
- Zilch: Nothing; zero.
- Zing: Energy, enthusiasm, or liveliness.
- Zither: A musical instrument consisting of a flat wooden sound box with numerous strings stretched across it, played by plucking or strumming.
- Zodiac: A belt of the heavens within about 8° either side of the ecliptic, including all apparent positions of the sun, moon, and most familiar planets. It is divided into twelve equal divisions or signs.
- Zombie: A fictional undead being created through the reanimation of a human corpse.
- Zonked: Completely exhausted or asleep.
- Zoology: The scientific study of the behavior, structure, physiology, classification, and distribution of animals.
- Zucchini: A variety of courgette; a summer squash.
- Zugzwang: A situation in which the obligation to make a move in one's turn is a serious, often decisive, disadvantage.
- Zumology: The study of fermentation in brewing.
- Zuppa: An Italian soup, often containing bread, eggs, and other ingredients.
- Zwitterion: A molecule or ion having separate positively and negatively charged groups.
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